Projekte Forschung


Wissenschaftliche Projekte


Mapping lymphocyte lineage decisions in vivo

Autor: Dr. Veit Buchholz

T cell immunity is based on the expansion and differentiation of naïve antigen-specific T cell populations into short-lived effector and long-lived memory subsets. In recent years we have developed a unique approach to study the emergence of adaptive immune responses starting out from individual CD8+ T cells (Buchholz et al., 2016). Strikingly, we found that the outcome of single-cell-derived immune responses in vivo is fundamentally uncertain [...]


Investigation of in-vivo antigen-specific T cell responses

Autor: Prof. Dr. med. Dirk Busch

Introduction The major focus of the Busch laboratory is to visualize and track antigen-specific T cell populations during in vivo antigen challenge. These studies are designed to increase our understanding of how T cell responses are regulated in vivo and how protective and long lasting immunity is established. This knowledge is of special interest for adoptive [...]


Role of the innate and adaptive regulatory immune response during chronic helminth infection

Autor: Prof. Dr. med. Clarissa Prazeres da Costa

Throughout his evolution, man has been parasitized by multicellular organisms, also called helminths or worms. This has led to an intriguing relationship between the immune system of the host and the parasite. The latter with its plethora of secreted molecules enables immune evasion and active suppression of host immune responses that ensures the survival of the parasite and the host How this is accomplished and what are the effects on other diseases (e.g. allergies, infectious diseases) are the main interests of our research group. [...]


Quantitative T cell immunology to inform immunotherapy and vaccination

Autor: Dr. rer. nat. Michael Floßdorf

In close collaboration with our clinical and experimental partners our group investigates the mechanistic basics of T cell differentiation, memory formation and the long-term dynamics of T cell responses during chronic infection and cancer; our goal is to inform immunotherapy and vaccination strategies. For this we devise data-driven mathematical models, which are tested and developed further in iterative cycles between theory and suitable in vivo experiments.[...]


Mechanisms of host-pathogen interaction during chronic infection, inflammation and carcinogenesis

Autor: Prof. Dr. med. Markus Gerhard

Our interest are chronic infections in the gastrointestinal tract, specifically the bacterial and immunological mechanisms involved in chronicity, immune escape, and tumor development upon chronic inflammatory processes [...]


Carbapenemase inhibitors and Pathoblockers

Author: Dr. rer. nat. Hannelore Meyer

Antibiotic resistances are – again - an increasing and long lasting threat to human health, lives, and wellbeing. Loss of antibiotic efficacy is expected to massively increase the number of infection related death cases, to jeopardize many therapies in modern medicine [...]


Human Immune Monitoring and Cellular Therapy

Autor: Dr. med. Michael Neuenhahn

An ever increasing number of immunocompromised patients (mainly due to secondary immune defects caused by the HIV pandemic, organ transplantation and intensified immunosuppressive treatment strategies for cancer and autoimmune diseases) remind clinicians every day that strategies to reconstitute the human immune system are highly warranted. Even though immunologists have used mouse models successfully during the [...]


Development of new Flow Cytometry based technologies and evaluation of parameters altering cell physiology or function after cell processing

Autor: Dr. rer. nat. Matthias Schiemann

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Engineering Immune Cells for Therapy

Author: Prof. Dr. Kathrin Schumann

Genetic manipulation of human primary cells has been largely impossible until recently, but advances in genome engineering methods offer new opportunities. Genome engineering of eukaryotic cells with CRISPR/Cas9 has been first described in 2012 and has since then revolutionized this research field [...]