Investigation of in-vivo antigen-specific T cell responses

The major focus of the Busch laboratory is to visualize and track antigen-specific T cell populations during in vivo antigen challenge. These studies are designed to increase our understanding of how T cell responses are regulated in vivo and how protective and long lasting immunity is established. This knowledge is of special interest for adoptive immunotherapy, diagnostic monitoring of T cell mediated immunity, and the development of new vaccination strategies.