Neo-epitopes derived from the mutated tumor suppressor gene RNF43 as targets for T cell therapy in pancreatic cancer
RNF43 is found to be mutated in 7 to 10% of pancreatic tumors. We have observed that loss of RNF43 function has an effect on pancreatic cell proliferation and migration. We are also investigating the effect that mutations in this protein have in pancreatic cancer progression using in vitro as well as in vivo models. Within the CRC 1321, in collaboration with the group of Dirk Busch, we are identifying neo-epitopes derived from RNF43 mutations observed in patients to use them as therapeutic targets for T cell therapy in pancreatic cancer.
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