Prof. Dr. med.
Markus Gerhard Group leader
Fax: +49 89 4140-4868
PD habil PhD
Raquel Mejías-Luque Group leader
Fax: +49 89 4140-4131
Mechanisms of host-pathogen interaction during chronic infection, inflammation and carcinogenesis
Bild: Susanne Dürr, 2023
Our research group is working on the mechanisms of tumor development in the gastrointestinal tract, especially during chronic inflammation elicited by Helicobacter pylori infection in the stomach. Another focus is the deregulation of the Wnt signaling pathway during bacterial infection in the intestine and colon. In parallel, we are interested in identifying targets to develop novel prophylactic approaches and therapeutic strategies for H. pylori infection and stomach cancer.
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- The roles of tissue resident T cells during H. pylori infection and after immunization
- Characterization of CD8+T cell responses during H. pylori infection
- The in-vivo function of gamma-glutamyltransferase, an essential virulence factor of Helicobacter pylori during colonization and immune response
- Non-canonical NF-ĸB signaling in H. pylori infection and gastric carcinogenesis
- Helicobacter infection and microbiota-dependent colonic inflammation and pathogenesis (CRC1371)
- H. pylori interaction with CEACAM receptors
- microbiome sequencing facility
- microbiome changes upon H. pylori infection in vivo
- role of microbiome during organ transplantation