Selected Publications

 

The Challenges for Women’s Health in sub-Saharan Africa: Lessons learned from an integrative multistakeholder workshop in Gabon. Habib M, Esen M, Honkpehedji J, Klug SJ, Lobmaier S, Vogg K, Bustinduy AL, Ullrich A, Reinhard-Rupp J, Adegnika AA, Prazeres da Costa C. Journal of Global Health. 2021;11:02002 (pending publication Sep 2021) IF 3.55


The Impact of the COVID-19 Pandemic on Pregnancy, Birth and Sexual & Reproductive Health and Rights – Perspectives from Germany and Somalia. Habib M, Lange U, Ludwig S, Prazeres da Costa C. Journal of Global Health. 2021;11:02002 (pending publication Sep 2021) IF 3.55


Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium. Vejzagić N, Prodjinotho UF, El-Khafif N, Huang R, Simeonov A, Spangenberg T, Prazeres da Costa C. PLOS Neglected Tropical Diseases. 2021 May 25;15(5):e0009432. doi: 10.1371 IF 4.33


HERA: a new era for health emergency preparedness in Europe? Villa S, van Leeuwen R, Gray CC, van der Sande M, Konradsen F, Fröschl G, Nord DG, Prazeres da Costa C, Ramirez-Rubio O, Abubakar I, Bärnighausen T, Casamitjana N, Berner-Rodoreda A, Cobelens F, Plasència A, Raviglione M. Lancet. 2021 Jun 5;397(10290):2145-2147. doi: 10.1016. PMID: 34015340 IF 9.45


Host-specific serum factors control the development and survival of Schistosoma mansoni. Anisuzzaman, Frahm S, Prodjinotho UF, Bhattacharjee S, Verschoor A, Prazeres da Costa C. Frontiers in Immunology. 2021 Apr 23;12:635622. doi: 10.3389 IF 6.76


Fetomaternal immune crosstalk modifies T cell priming through sustained changes to DC function. Lacorcia M, Bhattacharjee S, Laubhahn K, Alhamdan F, Ram M, Muschaweckh A, Potaczek DP, Kosinska A, Garn H, Protzer U, Renz H, Prazeres da Costa C. Journal of Allergy and Clinical Immunology. 2021 Mar 5:S0091-6749(21)00360-2. PMID: 33684437 IF 6.22


Fetal growth restriction in a cohort of migrants in Germany. Ankert J, Groten T, Pletz MW, Mishra S, Seliger G, Lobmaier SM, Prazeres da Costa C, Seidel V, von Weizsäcker K, Jablonka A, Dopfer C, Schleenvoigt BT. BMC Pregnancy and Childbirth. 2021 Feb 17;21(1):145. doi: 10.1186. PMID: 33596847; PMCID: PMC7890902 IF 2.94


Strategies for infection control and prevalence of anti-SARS-CoV-2 IgG in 4,554 employees of a university hostpital in Munich, Germany. Erber J, Kappler V, Haller B, Mijočević H, Galhoz A, Prazeres da Costa C, Gebhardt F, Graf N, Hoffmann D, Thaler M, Lorenz E, Roggendorf H, Kohlmayer F, Henkel A, Menden M P, Ruland J, Spinner C D, Protzer U, Knolle P, Lingor P. doi: 10.1101 (Preprint)


Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling. de Lange A, Prodjinotho UF, Tomes H, Hagen J, Jacobs BA, Smith K, Horsnell W, Sikasunge C, Hockman D, Selkirk ME, Prazeres da Costa C, Raimondo JV. PLOS Neglected Tropical Diseases. 2020 Dec 21;14(12) PMID: 33347447 IF 3.88


An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. De los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, Prazeres da Costa C, Chaker AM, Brüne B, Nüsing R, Jakobsson P, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von J. Science Translational Medicine. 2020 Apr 22;12(540) PMID: 32321863 IF 16.3*


Host immune responses during Taenia solium Neurocysticercosis infection and treatment. Prodjinotho UF, Lema J, Lacorcia M, Schmidt V, Vejzagic N, Sikasunge C, Ngowi B, Winkler AS, Prazeres da Costa C. PLOS Neglected Tropical Diseases 2020 Apr 16;14(4):e0008005. PMID: 32298263 IF 6.4*


Dynamic, helminth-induced immune modulation influences the outcome of acute and chronic hepatitis B virus infection. Eva Loffredo-Verde E, Bhattacharjee S, Malo A, Hasreiter J, Kosinska A, Ringelhan M, Heikenwaelder M, Protzer U, Clarissa U. Prazeres da Costa C. The Journal of Infectious Diseases. 2019 Dec 25 PMID: 31875228 IF 5.2


The 2017 Oslo conference report on neglected tropical diseases and emerging/re-emerging infectious diseases – focus on populations underserved. Klohe K, Amuasi J, Kaducu JM, Haavardsson I, Bogatyreva E, Onarheim KH, Harrison W, Kristensen F, Prazeres da Costa C, Winkler AS. Infectious Diseases of Poverty (2019) 8:40 PMID: 31138293 IF 2.7


Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country. Ludwig E, Harder J, Lacorcia M, Honkpehedji JY, Nouatin O, van Dam GJ, Corstjens PLAM, Sartono E, Esen M, Lobmaier SM, Adegnika AA, Prazeres da Costa C. Scientific Reports. 2019 Oct 31;9(1):15776. PMID: 31673046 IF 4.8


Quantitative assay for ciprofloxacin and enrofloxacin formulations. Moed S, Hall M, Lee N, Prazeres da Costa C, Rodland E K, Shemirani A I, Clifford K, Desai D, Zaman M H. Journal of Global Health Reports. 2019 Aug 1;3:e2019044. doi:10.29392 IF 3.55


Concomitant infection of S. mansoni and H. pylori promotes promiscuity of antigen experienced cells and primes the liver for a lower fibrotic response. Bhattacharjee S, Loffredo-Verde, Toska A, Flossdorf M, Mejías-Luque R, Gerhard M and Prazeres da Costa C. Cell Reports. 2019 Jul 2;28(1):231-244.e5. PMID: 31269443 IF 8.57


A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing. Frahm S, Anisuzzaman DVM, Prodjinotho F, Vejzagić N, Verschoor A, Prazeres da Costa C. PLOS Neglected Tropical Diseases 2019 Jan 28;13(1): e0006590. doi: 10.1371. PMID: 30689639 IF 4.4


Maternal Schistosomiasis: Immunomodulatory Effects with Lasting Impact on Allergy and Vaccine Responses. Lacorcia M, Prazeres da Costa C. Frontiers in Immunology. doi: 10.3389. 2018.02960 PMID: 30619318 IF 5.5


Maternal helminth infections and the shaping of offspring immunity. Dewals BG, Layland LE, Prazeres da Costa C, Horsnell WG.  Parasite Immunology. 2018 Oct 29:e12599. doi: 10.1111. PMID: 30372527 IF 2.8


Antimicrobial resistance in livestock and poor quality veterinary medicines. Clifford K, Desai D, Prazeres da Costa C, Meyer H, Klohe K, Winkler AS, Rahman T, Islam T, Zaman MH. Bulletin of the World Health Organization. 2018 Sep 1;96(9):662-664. doi: 10.2471. PMID: 30262949 IF 6.8


Positive phototropism is accelerated in Biomphalaria glabrata snails by infection with Schistosoma mansoni. Maeda H, Hatta T, Tsubokawa D, Mikami F, Nishimaki T, Nakamura T, Anisuzzaman, Matsubayashi M, Ogawa M, Prazeres da Costa C, Tsuji N. Parasitology International. 2018 Jun 9;67(5):609-611. doi: 10.1016. PMID: 29894729 IF 2.1


Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses. Kaisar MMM, Ritter M, Del Fresno C, Jónasdóttir HS, van der Ham AJ, Pelgrom LR, Schramm G, Layland LE, Sancho D, Prazeres da Costa C, Giera M, Yazdanbakhsh M, Everts B.  PLOS Biology. 2018 Apr 18;16(4):e2005504. PMID: 29668708 IF 9.1


Neglected tropical diseases - the present and the future. Winkler AS, Klohe K, Schmidt V, Haavardsson I, Abraham A, Prodjinotho UF, Ngowi B, Sikasunge C, Noormahomed E, Amuasi J, Kaducu J, Ngowi H, Abele-Ridder B, Harrison WE, Prazeres da Costa C. Journal of the Norwegian Medical Association. 2018 Jan 2;138(3) PMID: 29411594 IF 0.13


Nutrition – A global challenge for health. Klohe K, Prazeres da Costa C, Lien N, Holmboe-Ottesen G, Rychlik M, Haavardsson I, Stordalen G, Singh S, Engebretsen I, Iversen PO, Winkler AS. Journal of the Norwegian Medical Association. 2017 Dec 12;137(23-24). PMID: 29231665 IF 0.13


Usefulness of 1,3 Beta-D-Glucan Detection in non-HIV Immunocompromised Mechanical Ventilated Critically Ill Patients with ARDS and Suspected Pneumocystis jirovecii Pneumonia. Lahmer T, Prazeres da Costa C, Held J, Rasch S Ehmer U, Schmid RM, Huber W. Mycopathologia. 2017 Aug;182(7-8):701-708. PMID: 28378239 IF 1.5


First case of human peritoneal cysticercosis mimicking peritoneal carcinosis: necessity of laparoscopy and histologic assessment for the correct diagnosis. Rudelius M, Brehm K, Poelcher M, Spinner C, Rosenwald A, Prazeres da Costa C. JMM Case Reports. 2017 Jun 8;4(6) PMID: 29026624 IF 0.47


Chronic schistosomiasis during pregnancy epigenetically reprograms T cell differentiation in offspring of infected mothers. Klar K, Perchermeier S, Bhattacharjee S, Harb H, Adler T, Istvanffy R, Loffredo-Verde E, Oostendorp R, Renz H, Prazeres da Costa C. European Journal of Immunology. 2017 May;47(5):841-847. PMID: 28271497 IF 4.18


Vav proteins are key regulators of Card9 signaling for innate antifungal immunity. Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J. Cell Reports. 2016 Dec 6 PMID: 27926862 IF 8.57


Parasites, microbiota and metabolic disease. Bhattacharjee S, Kalbfuss N, Prazeres da Costa C. Parasite Immunology. 2016 Oct 7. doi: 10.1111. PMID: 27716947 IF 2.2



Microbes and asthma: Opportunities for intervention. Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C. Journal of Allergy and Clinical Immunology. 2016 Mar;137(3):690-7, PMID: 26947981 IF 12.48


An Unusual Presentation of Neurocysticercosis: A Space-Occupying Lesion in the Fourth Ventricle Associated with Progressive Cognitive Decline. Kurz C, Schmidt V, Poppert H, Wilkins P, Noh J, Poppert S, Schlegel J, Delbridge C, Prazeres da Costa C, Winkler AS.  American Journal of Tropical Medicine and Hygiene. 2016 Jan;94(1):172-5. doi: 10.4269. PMID: 26621562 IF 2.7



Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T cell phenotype. Loffredo-Verde E, Abdel-Aziz I, Layland L, Busch DH, Prazeres da Costa C. Parasite Immunology. 2015 Jan 5. doi: 10.1111. PMID: 25559085 IF 2.2


Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation. Straubinger K, Paul S, Prazeres da Costa O, Buch T, Busch DH, Layland, Prazeres da Costa C. Journal of Allergy and Clinical Immunology. 2014 Dec 18. pii: S0091-6749(14)00794-5. PMID: 25042744 IF 11.48


Maternal helminth infections. Straubinger K, Prazeres da Costa C. Advances in Experimental Medicine and Biology. Oct 2014;828:27-48 PMID: 25253026 IF 2.1



Helicobacter pylori-Induced IL-1β Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island. Semper RP, Mejías-Luque R, Groß C, Anderl F, Müller A, Vieth M, Busch DH, Prazeres da Costa C, Ruland J, Groß O, Gerhard M. Journal of Immunology. 2014 Oct 1;193 (7):3566-76. PMID: 25172489 IF 5.6


T Cell-Derived IL-4/IL-13 Protects Mice against Fatal Schistosoma mansoni Infection Independently of Basophils Schwartz C, Oeser K, Prazeres da Costa C, Layland LE, Voehringer D.  Journal of Immunology. 2014 Oct 1;193(7):3590-9. PMID: 25172500 IF 5.6


Functional relevance of NLRP3 inflammasome-mediated IL-1 during acute allergic airway inflammation. Ritter M, Straubinger K, Schmidt S, Busch D, Hagner S, Garn H, Layland L, Prazeres da Costa C.  Clinical and Experimental Immunology. 2014 Nov;178(2):212-23. PMID: 24943899 IF 3.3


Lack of Host Gut Microbiota Alters Immune Responses and Intestinal Granuloma Formation during Schistosomiasis. Holzscheiter M, Layland LE, Loffredo-Verde E, Mair K, Vogelmann R, Langer R, Wagner H, Prazeres da Costa C. Clinical and Experimental Immunology. 2014 Feb 30. doi: 10.1111. PMID: 24168057 IF 3.3


Schistosoma mansoni-mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells. Layland LE, Straubinger K, Ritter M, Loffredo-Verde E, Garn H , Sparwasser T, Prazeres da Costa C. PLOS Neglected Tropical Diseases 2013 Aug 15;7(8):e2379. PMID: 23967364 IF 4.72


Fetal-maternal alignment of regulatory T cells correlates with Interleukin 10 and Bcl-2 upregulation in pregnancy. Santner-Nanan B, Straubinger K, Hsu P, Parnell G, Tang B, Xu B, Makris A, Hennessy A, Peek M, Busch DH, Prazeres da Costa C, Nanan R. Journal of Immunology. 2013 Jul 1;191(1):145-153. PMID: 23733877 IF 5.6


The Mincle-activating Adjuvant TDB Induces MyD88-dependent Th1 and Th17 Responses through IL-1R signaling.  Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger E, Prazeres da Costa C, Lang R. PLOS One. 2013;8(1): e53531: PMID: 23308247 IF 3.5


The Mincle-activating Adjuvant TDB Induces MyD88-dependent Th1 and Th17 Responses through IL-1R signaling.  Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger E, Prazeres da Costa C, Lang R. PLOS One. 2013;8(1): e53531: PMID: 23308247 IF 3.5


Molecular diagnosis of subcutaneous Spirometra erinaceieuropaei sparganosis in a Japanese immigrant. Tappe D, Berger L, Haeupler A, Muntau B, Racz P, Harder Y, Specht K, Prazeres da Costa C,  Poppert S.  American Journal of Tropical Medicine and Hygiene. 2012 Nov;88(1):198-202. PMID: 23166198 IF 2.53



Primary extrahepatic alveolar echinococcosis of the lumbar spine and the psoas muscle: A Case Report and Review of Literature. Nell M, Burgkart RH, Gradl G, von Eisenhart-Rothe R, Schaeffeler C, Trappe D, Prazeres da Costa C, Gradinger R, Kirchhoff C. Annals of Clinical Microbiology and Antimicrobials. 2011 Apr 15;10(1):13 PMID: 21496254 IF 1.51


Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C. Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov 23;107(47):20459-64. PMID: 21059925 IF 9.81


An imported case of external ophthalmomyiasis caused by the sheep botfly (Oestrus ovis) – case report. Abdel-Aziz I, Layland LE, Prazeres da Costa C. Scientia Parasitologica. 2010 Dec 11;4: 207-211 IF 1.53


Pronounced phenotype in activated regulatory T cells during a chronic helminth infection. Layland LE, Mages J, Loddenkemper C, Hoerauf A, Wagner H, Lang R, Prazeres da Costa C. Journal of Immunology. 2010 Jan 15;184(2):713-24. PMID: 20007528 IF: 5.6


Regulatory T cells primed in the absence of TLR2 fail to control Immunopathology and TH responses in Schistosomiasis. Layland LE, Rad R, Wagner H, Prazeres da Costa C. European Journal of Immunology. 2007 Aug;37(8):2174-84. IF 4.56


Multicystic tumor in the fourth ventricle: consider neurocysticercosis. Prazeres da Costa C, von Einsiedel HG, Disko R, Berthele A.  Journal of Neurology. 2006 Aug;253(8):1092-3. PMID: 16649100 IF 1.44



CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Rad R, Brenner L, Bauer S, Schwendy S, Layland L, Prazeres da Costa C, Reindl W, Dossumbekova A, Friedrich M, Saur D, Wagner H, Schmid RM, Prinz C. Gastroenterology. 2006 Aug;131(2):525-37 PMID: 16890606 IF 0.6



Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni infected MyD88-deficient mice. Layland L, Wagner H, Prazeres da Costa C. European Journal of Immunology. 2005 Nov;35(11):3248-57 PMID: 16276483 IF 7.7


Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction. Rodriguez N, Fend F, Jennen L, Schiemann M, Wantia N, Prazeres da Costa C, Durr S, Heinzmann U, Wagner H, Miethke T. Journal of Immunology. 2005 Apr 15;174(8):4836-44. PMID: 15814710 IF 5.8


Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Prazeres da Costa C, Wantia N, Busch D, Durr S, Wagner H, Miethke T. European Journal of Immunology. 2004 Oct;34(10):2874-84. PMID: 15368304 IF 5.9


Recruitment of Chlamydia pneumoniae-infected macrophages to the carotid artery wall in noninfected, nonatherosclerotic mice. May A E, Redecke V, Grüner S, Schmidt R, Massberg S, Miethke T, Ryba B, Prazeres da Costa C, Schömig A, Neumann F J. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003 May 1;23(5):789-94. doi: 10.1161. PMID: 12663369 IF 5.98*



The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin. Prebeck S, Brade H, Kirschning CJ, Prazeres da Costa CP, Durr S, Wagner H, Miethke T. Microbes and Infection. 2003 May;5(6):463-70. PMID: 12758273 IF 2.4




Role of IgG-seropositivity to Chlamydia pneumoniae in early thrombotic events after coronary stent placement. Prazeres da Costa C, Neumann FJ, Kastrati A, Stallforth I, Schmid M, Joghetai N, Prebeck S, Wagner H, Miethke T. Atherosclerosis. 2003 Jan;166(1):171-6. PMID: 12482564 IF 4.0


Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure. Donath B, Fischer C, Page S, Prebeck S, Jilg N, Weber M, Prazeres da Costa C, Neumeier D, Miethke T, Brand K. Atherosclerosis. 2002 Nov;165(1):79-88. PMID: 12208473 IF 3.4



Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae. Prazeres da Costa C, Kirschning CJ, Busch D, Durr S, Jennen L, Heinzmann U, Prebeck S, Wagner H, Miethke T. European Journal of Immunology. 2002 Sep;32(9):2460-70. PMID: 12207330 IF 5.0


The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Prazeres da Costa C, Rammensee HG, Wagner H, Schild H. Journal of Biological Chemistry. 2002 Jun 7;277(23):20847-53. PMID: 11912201 IF 4,1


Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells. Prebeck S, Kirschning C, Durr S, Prazeres da Costa C, Donath B, Brand K, Redecke V, Wagner H, Miethke T. Journal of Immunology. 2001 Sep 15;167(6):3316-23. PMID: 11544320 IF 6.0


Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. Vabulas RM, Ahmad-Nejad P, Prazeres da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H. Journal of Biological Chemistry. 2001 Aug 17;276(33):31332-9. 2001 Jun 11. PMID: 11402040 IF 7.3

Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebo-controlled trial. Neumann F, Kastrati A, Miethke T, Pogatsa-Murray G, Mehilli J, Valina C, Jogethaei N, Prazeres da Costa C, Wagner H, Schomig A. Lancet. 2001 Jun 30;357(9274):2085-9. PMID: 11445102 IF 10.2