Selected Publications

 

Marrium Habib, Meral Esen, Josiane Honkpehedji, Stefanie J. Klug, Silvia Lobmaier, Kathrin Vogg, Amaya L. Bustinduy, Andreas Ullrich, Jutta Reinhard-Rupp, Ayola Akim Adegnika, Clarissa Prazeres da Costa

The Challenges in Women’s Health in sub-Saharan Africa: Lessons learned from an integrative multistakeholder workshop in Gabon.

(accepted March J Global Health)


Marrium Habib, Ute Lange, Sabine Ludwig, Clarissa Prazeres da Costa

The Impact of the COVID-19 Pandemic on Pregnancy, Birth and Sexual & Reproductive Health and Rights – Perspectives from Germany and Somalia.

(accepted Feb 2021 Global Health)



Vejzagić N, Prodjinotho UF, El-Khafif N, Huang R, Simeonov A, Spangenberg T, Prazeres da Costa C.

Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium.

PLoS Negl Trop Dis. 2021 May 25;15(5):e0009432. DOI: 10.1371/journal.pntd.0009432 (link is external)



Anisuzzaman, S. Frahm, U.F. Prodjinotho, S. Bhattacharjee, A. Verschoor, and C. Prazeres da Costa.

Host-Specific Serum Factors Control the Development and Survival of Schistosoma mansoni.

Front. Immunol., 2021, https://doi.org/10.3389/fimmu.2021.635622(link is external)


Lacorcia M, Bhattacharjee S, Laubhahn K, Alhamdan F, Ram M, Muschaweckh A, Potaczek DP, Kosinska A, Garn H, Protzer U, Renz H, Prazeres da Costa C

Fetomaternal immune crosstalk modifies T cell priming through sustained changes to DC function.

J The Journal of allergy and clinical immunology, 2021 https://doi.org/10.1016/j.jaci.2021.02.031


de Lange A, Prodjinotho UF, Tomes H, Hagen J, Jacobs BA, Smith K, Horsnell W, Sikasunge C, Hockman D, Selkirk ME, Prazeres da Costa C, Raimondo JV. 

Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling.

PLoS Negl Trop Dis. 2020 Dec21;14(12) PMID: 33347447 IF 3.88 DOI: 10.1371/journal.pntd.0008966 (link is external)


De los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A,Prazeres da Costa C, Chaker AM, Brüne B, Nüsing R, Jakobsson P, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.

J. Sci Transl Med 2020 Apr 22;12(540):eaay0605.DOI: 10.1126/scitranslmed.aay0605 (link is external)



Prodjinotho UF, Lema J, Lacorcia M, Schmidt V, Vejzagic N, Sikasunge C, Ngowi B, Winkler AS, Prazeres da Costa

Host immune responses during Taenia solium Neurocysticercosis infection and treatment.

CPLOS NTD April 16, 2020 https://doi.org/10.1371/journal.pntd.0008005(link is external)


Ludwig E, Harder J, Lacorcia M, Honkpehedji JY, Nouatin O, van Dam GJ, Corstjens PLAM, Sartono E, Esen M, Lobmaier SM, Adegnika AA, Prazeres da Costa C 

Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country.

Sci Rep. 2019 Oct 31;9(1):15776. DOI: 10.1038/s41598-019-52074-z(link is external)


Eva Loffredo-Verde E, Bhattacharjee S, Malo A, Hasreiter J, Kosinska A, Ringelhan M, Heikenwaelder M, Protzer U*, Clarissa U. Prazeres da Costa C*

Dynamic, helminth-induced immune modulation influences the outcome of acute and chronic hepatitis B virus infection.

J Infect Dis.(link is external) 2019 Dec 25


Bhattacharjee S, Loffredo-Verde, Toska A,  Flossdorf M, Mejías-Luque R, Gerhard M* and Prazeres da Costa C*.

Concomitant infection of S. mansoni and H. pylori promotes promiscuity of antigen experienced cells and primes the liver for a lower fibrotic response.

Cell Rep.(link is external) 2019 Jul 2;28(1):231-244.e5.


Klohe K, Amuasi J, Kaducu JM, Haavardsson I, Bogatyreva E, Onarheim KH, Harrison W, Kristensen F, Prazeres da Costa C* and Winkler AS*.

The 2017 Oslo conference report on neglected tropical diseases and emerging/re-emerging infectious diseases – focus on populations underserved.

Infectious Diseases of Poverty (2019) 8:40 DOI: 10.1186/s40249-019-0550-8 (link is external)


Frahm S, Anisuzzaman DVM, Prodjinotho F, Vejzagić N, Verschoor A and Prazeres da Costa C;

A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

PLOS NTD 2019 Jan 28;13(1): e0006590. doi: 10.1371 DOI: 10.1371/journal.pntd.0006590 (link is external)


Clifford K, Desai D, Prazeres da Costa C, Meyer H, Klohe K, Winkler AS, Rahman T, Islam T, Zaman MH.

Antimicrobial resistance in livestock and poor quality veterinary medicines.

Bull World Health Organ. 2018 Sep 1;96(9):662-664. DOI: 10.2471/BLT.18.209585 (link is external)


Dewals BG, Layland LE, Prazeres da Costa C, Horsnell WG

Maternal helminth infections and the shaping of offspring immunity.

Parasite Immunol. 2018 Oct 29:e12599.DOI: 10.1111/pim.12599 (link is external)



Lacorcia M and Prazeres da Costa C;

Maternal Schistosomiasis: Immunomodulatory Effects with Lasting Impact on Allergy and Vaccine Responses.

Front. Immunol. DOI: 10.3389/fimmu.2018.02960 (link is external)


Maeda H, Hatta T, Tsubokawa D, Mikami F, Nishimaki T, Nakamura T, Anisuzzaman, Matsubayashi M, Ogawa M, da Costa CP, Tsuji N.

Positive phototropism is accelerated in Biomphalaria glabrata snails by infection with Schistosoma mansoni.

Parasitol Int. 2018 Jun 9;67(5):609-611. DOI: 10.1016/j.parint.2018.06.003 (link is external)



Kaisar MMM, Ritter M, Del Fresno C, Jónasdóttir HS, van der Ham AJ, Pelgrom LR, Schramm G, Layland LE, Sancho D, Prazeres da Costa C, Giera M, Yazdanbakhsh M, Everts B.

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

PLoS Biol. 2018 Apr 18;16(4):e2005504. DOI: 10.1371/journal.pbio.2005504 (link is external)


Winkler AS, Klohe K, Schmidt V, Haavardsson I, Abraham A, Prodjinotho UF, Ngowi B, Sikasunge C, Noormahomed E, Amuasi J, Kaducu J, Ngowi H, Abele-Ridder B, Harrison WE, Prazeres da Costa C.

Neglected tropical diseases - the present and the future.

Tidsskr Nor Laegeforen. 2018 Jan 2;138(3) DOI: 10.4045/tidsskr.17.0678 (link is external)


Rudelius M, Brehm K, Poelcher M, Spinner C, Rosenwald A, da Costa CP.

First case of human peritoneal cysticercosis mimicking peritoneal carcinosis: necessity of laparoscopy and histologic assessment for the correct diagnosis.

JMM Case Rep. 2017 Jun 8;4(6) DOI: 10.1099/jmmcr.0.005097 (link is external)


Klohe K, Prazeres da Costa C, Lien N, Holmboe-Ottesen G, Rychlik M, Haavardsson I, Stordalen G, Singh S, Engebretsen I, Iversen PO, Winkler AS.

Nutrition – A global challenge for health.

Tidsskr Nor Laegeforen. 2017 Dec 12;137(23-24). DOI: 10.4045/tidsskr.17.0679 (link is external)


Klar K, Perchermeier S, Bhattacharjee S, Harb H, Adler T, Istvanffy R, Loffredo-Verde E, Oostendorp R, Renz H, Prazeres da Costa C.

Chronic schistosomiasis during pregnancy epigenetically reprograms T cell differentiation in offspring of infected mothers.

Eur J Immunol March 2017 DOI: 10.1002/eji.201646836 (link is external)


Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J.

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Cell Rep. 2016 Dec 6 DOI: 10.1016/j.celrep.2016.11.018 (link is external)


Bhattacharjee S, Kalbfuss N, Prazeres da Costa C.

Parasites, microbiota and metabolic disease.

Parasite Immunol. 2016 Oct 7. DOI: 10.1111/pim.12390 (link is external)


Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

Microbes and asthma: Opportunities for intervention.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. DOI: 10.1016/j.jaci.2016.01.004 (link is external)


Kurz C, Schmidt V, Poppert H, Wilkins P, Noh J, Poppert S, Schlegel J, Delbridge C, da Costa CP, Winkler AS.

An Unusual Presentation of Neurocysticercosis: A Space-Occupying Lesion in the Fourth Ventricle Associated with Progressive Cognitive Decline.

Am J Trop Med Hyg. 2016 Jan;94(1):172-5. DOI: 10.4269/ajtmh.15-0099 (link is external). Epub 2015 Nov 30.


Loffredo-Verde E, Abdel-Aziz I, Layland L, Busch DH, Prazeres da Costa C.

Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T cell phenotype.

Parasite Immunol. 2015 Jan 5. DOI: 10.1111/pim.12171 (link is external)


Straubinger K, Prazeres da Costa C.

Maternal helminth infections.

Adv Exp Med Biol. Oct 2014;828:27-48 DOI: 10.1007/978-1-4939-1489-0_2 (link is external)


Semper, R.P., Mejias-Luque, R., Gross, C., Anderl, F., Muller, A., Vieth, M., Busch, D.H., Prazeres da Costa, C., Ruland, J., Gross, O., and Gerhard, M.

Helicobacter pylori-Induced IL-1beta Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island.

J Immunol 2014. doi: 10.4049/jimmunol.1400362. DOI: 10.4049/jimmunol.1400362 (link is external)


Schwartz C, Oeser K, Prazeres da Costa C, Layland LE, Voehringer D.

T Cell-Derived IL-4/IL-13 Protects Mice against Fatal Schistosoma mansoni Infection Independently of Basophils

J Immunol. 2014 Oct 1;193(7):3590-9. DOI: 10.4049/jimmunol.1401155 (link is external)


Ritter M, Straubinger K, Schmidt S, Busch D, Hagner S, Garn H, Layland L, Prazeres da Costa

Functional relevance of NLRP3 inflammasome-mediated IL-1bduring acute allergic airway inflammation.

CClin Exp Immunol. 2014 Nov;178(2):212-23 DOI: 10.1111/cei.12400 (link is external)


Maternal Helminth Infection Determines Offspring Susceptibility to Allergic Airway Inflammation.

Straubinger K, Paul S, Prazeres da Costa O, Buch T, Busch DH, Layland L and Prazeres da Costa C.

J Allergy Clin Immunol. 2014Jul 18. pii: S0091-6749(14)00794-5


Holzscheiter M, Layland LE, Loffredo-Verde E, Mair K, Vogelmann R, Langer R, Wagner H, Prazeres da Costa C.

Lack of Host Gut Microbiota Alters Immune Responses and Intestinal Granuloma Formation during Schistosomiasis.

Clin Exp Immunol. 2013 Oct 30. DOI: 10.1111/cei.12230 (link is external)


Layland LE, Straubinger K, Ritter M, Loffredo-Verde E, Garn H, Sparwasser T, Prazeres da Costa C.

Schistosoma mansoni-mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells.

PLOS NTD 2013 Aug 15;7(8):e2379. DOI: 10.1371/journal.pntd.0002379 (link is external)


Santner-Nanan B, Straubinger K, Hsu P, Parnell G, Tang B, Xu B, Makris A, Hennessy A, Peek M, Busch DH, Prazeres da Costa, Cand Nanan RJ

Fetal-maternal alignment of regulatory T cells correlates with Interleukin 10 and Bcl-2 upregulation in pregnancy.

Immunol. 2013 Jul 1;191(1):145-153. DOI: 10.4049/jimmunol.1203165 (link is external)


Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger E,da Costa CP and Lang R.

The Mincle-activating Adjuvant TDB Induces MyD88-dependent Th1 and Th17 Responses through IL-1R signaling. 

PLoS One.2013;8(1): e53531. DOI: 10.1371/journal.pone.0053531 (link is external)


Tappe D, Berger L, Haeupler A, Muntau B, Racz P, Harder Y, Specht K, Prazeresda Costa C,  Poppert S.

Molecular diagnosis of subcutaneous Spirometra erinaceieuropaeisparganosis in a Japanese immigrant.

Am J Trop Med Hyg. 2013 Jan;88(1):198-202. DOI: 10.4269/ajtmh.2012.12-0406 (link is external)


Nell M, Burgkart RH, Gradl G, von Eisenhart-Rothe R, Schaeffeler C, Trappe D,Prazeres da Costa C, Gradinger R, Kirchhoff C.

Primary extrahepatic alveolar echinococcosis of the lumbar spine and the psoas muscle: A Case Report and Review of Literature.

Ann Clin Microbiol Antimicrob.2011 Apr 15;10(1):13. DOI: 10.1186/1476-0711-10-13 (link is external)


Abdel-Aziz I, Layland LE, Prazeres da Costa C.

An imported case of external ophthalmomyiasis caused by the sheep botfly (Oestrus ovis) – case report.

Sci Parasitologica. 2010 Dec 11;4: 207-211


Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C.

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

Proc Natl Acad Sci U S A. 2010 Nov 8. DOI: 10.1073/pnas.1010337107 (link is external)


Layland LE, Mages J, Loddenkemper C, Hoerauf A, Wagner H, Lang R,da Costa CU.

Pronounced phenotype in activated regulatory T cells during a chronic helminth infection.

J Immunol. 2010 Jan 15;184(2):713-24. Epub 2009 Dec 9. DOI: 10.4049/jimmunol.0901435 (link is external)


Layland LE, Rad R, Wagner H,da Costa CU

Regulatory T cells primed in the absence of TLR2 fail to control Immunopathology and TH responses in Schistosomiasis.

Eur J Immunol. 2007 Aug;37(8):2174-84. https://doi.org/10.1002/eji.200737063(link is external)


Costa CU, von Einsiedel HG, Disko R, Berthele A.

Multicystic tumor in the fourth ventricle: consider neurocysticercosis.

J Neurol.2006 Aug;253(8):1092-3. DOI: 10.1007/s00415-006-0155-6 (link is external)


Rad R, Brenner L, Bauer S, Schwendy S, Layland L,da Costa CP, Reindl W, Dossumbekova A, Friedrich M, Saur D, Wagner H, Schmid RM, Prinz C

CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo

Gastroenterology.2006 Aug;131(2):525-37. DOI: 10.1053/j.gastro.2006.05.001 (link is external)


Layland L, Wagner H,Prazeres da Costa C

Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni infected MyD88-deficient mice.

Eur J Immunol.2005 Nov;35(11):3248-57. DOI: 10.1002/eji.200526273 (link is external)


Rodriguez N, Fend F, Jennen L, Schiemann M, Wantia N, Prazeres da Costa CU, Dürr S, Heinzmann U, Wagner H, Miethke T.

Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction.

J Immunol.2005 Apr 15;174(8):4836-44. DOI: 10.4049/jimmunol.174.8.4836 (link is external)


da Costa CP, Wantia N, Kirschning C, Busch D, Rodriguez N, Wagner H, Miethke T.

Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo.

Eur J Immunol. 2004 Oct;34(10):2874-84. DOI: 10.1002/eji.200425101(link is external)


Prebeck S, Brade H, Kirschning CJ, da Costa CP, Dürr S, Wagner H, Miethke T.

The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin.

Microbes Infect. 2003 May;5(6):463-70. DOI: 10.1016/s1286-4579(03)00063-7 (link is external)


da Costa CP, Neumann FJ, Kastrati A, Stallforth I, Schmid M, Joghetai N, Prebeck S, Wagner H, Miethke T.

Role of IgG-seropositivity to Chlamydia pneumoniae in early thrombotic events after coronary stent placement.

Atherosclerosis. 2003 Jan;166(1):171-6.). DOI: 10.1016/s0021-9150(02)00326-x (link is external)


Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H.

The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway.

J Biol Chem. 2002 Jun 7;277(23):20847-53. DOI: 10.1074/jbc.M200425200 (link is external)


Donath B, Fischer C, Page S, Prebeck S, Jilg N, Weber M, da Costa C, Neumeier D, Miethke T, Brand K.

Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure.

Atherosclerosis. 2002 Nov;165(1):79-88. DOI: 10.1016/s0021-9150(02)00198-3 (link is external)


da Costa CP, Kirschning CJ, Busch D, Dürr S, Jennen L, Heinzmann U, Prebeck S, Wagner H, Miethke T.

Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae.

Eur J Immunol. 2002 Sep;32(9):2460-70. DOI: 10.1002/1521-4141(200209)32:9<2460::AID-IMMU2460>3.0.CO;2-M (link is external)


Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H.

Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells.

J Biol Chem. 2001 Aug 17;276(33):31332-9. 2001 Jun 11. DOI: 10.1074/jbc.M103217200 (link is external)


Prebeck S, Kirschning C, Dürr S,da Costa C, Donath B, Brand K, Redecke V, Wagner H, Miethke T.

Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells.

J Immunol. 2001 Sep 15;167(6):3316-23. DOI: 10.4049/jimmunol.167.6.3316 (link is external)


Neumann F, Kastrati A, Miethke T, Pogatsa-Murray G, Mehilli J, Valina C, Jogethaei N,da Costa CP, Wagner H, Schomig A.

Treatment of Chlamydia pneumoniae infection with roxithromycin and effect on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebo-controlled trial.

Lancet. 2001 Jun 30;357(9274):2085-9. DOI: 10.1016/s0140-6736(00)05181-3 (link is external)