Selected Publications                                           

Hamway Y, Taxauer K, Moonens K, Neumeyer V, Fischer W, Schmitt V, Singer BB, Remaut H, Gerhard M, Mejías-Luque R. Cysteine Residues in Helicobacter pylori Adhesin HopQ Are Required for CEACAM-HopQ Interaction and Subsequent CagA Translocation. Microorganisms. 2020 Mar 25;8(4):465. (Full Text(link is external); Abstract(link is external))

Guo Y, Zhang Y, Gerhard M, Gao JJ, Mejias-Luque R, Zhang L, Vieth M, Ma JL, Bajbouj M, Suchanek S, Liu WD, Ulm K, Quante M, Li ZX, Zhou T, Schmid R, Classen M, Li WQ, You WC, Pan KF. Effect of Helicobacter pylori on Gastrointestinal Microbiota: A Population-Based Study in Linqu, a High-Risk Area of Gastric Cancer. Gut. 2019 Dec 19;gutjnl-2019-319696. (Full text(link is external); Abstract(link is external))

Hornburg D, Kruse T, Anderl F, Daschkin C, Semper RP, Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F, Gerhard M. A Mass Spectrometry Guided Approach for the Identification of Novel Vaccine Candidates in Gram-Negative Pathogens. Sci Rep. 2019 Nov 22;9(1):17401. (Full Text(link is external); Abstract(link is external))

Semper RP, Vieth M, Gerhard M, Mejías-Luque R. Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses. J Immunol. 2019 Oct 15;203(8):2183-2193. (Full Text(link is external); Abstract(link is external))

Bhattacharjee S, Mejías-Luque R, Loffredo-Verde E, Toska A, Flossdorf M, Gerhard M, Prazeres da Costa C. Concomitant Infection of S. Mansoni and H. Pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response. Cell Rep. 2019 Jul 2;28(1):231-244.e5. (Full Text(link is external); Abstract(link is external))                

Mejías-Luque R, Lozano-Pope I, Wanisch A, Heikenwälder M, Gerhard M, Obonyo M. Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. Sci Rep. 2019 May 7;9(1):7030. (Full Text(link is external); Abstract(link is external))

Neumeyer V, Vieth M, Gerhard M, Mejías-Luque R. Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology. Cancers (Basel). 2019 Mar 16;11(3). pii: E372. (Full Text(link is external); Abstract(link is external))

Neumeyer V, Grandl M, Dietl A, Brutau-Abia A, Allgäuer M, Kalali B, Zhang Y, Pan KF, Steiger K, Vieth M, Anton M, Mejías-Luque R, Gerhard M. Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Carcinogenesis. 2019 Jun 10;40(4):551-559. (Full Text(link is external); Abstract(link is external))

Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mejías-Luque R, Singer BB, Backert S, Gerhard M, Remaut H. Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs. EMBO J. 2018 Jul 2;37(13). (Full Text(link is external); Abstract(link is external))

Quintana I, Mejías-Luque R, Terradas M, Navarro M, Piñol V, Mur P, Belhadj S, Grau E, Darder E, Solanes A, Brunet J, Capellá G, Gerhard M, Valle L. Evidence suggests that germline RNF43 mutations are a rare cause of serrated polyposis. Gut. 2018 Jan 12. (Full Text(link is external); Abstract(link is external))

Formichella L, Romberg L, Meyer H, Bolz C, Vieth M, Geppert M, Göttner G, Nölting C, Schepp W, Schneider A, Ulm K, Wolf P, Holster IL, Kuipers EJ, Birkner B, Soutschek E, Gerhard M. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status. J Immunol Res. 2017;2017:8394593. (Full Text(link is external); Abstract(link is external)

Mejías-Luque R, Gerhard M. Immune Evasion Strategies and Persistence of Helicobacter pylori. Curr Top Microbiol Immunol. 2017;400:53-71. (Full Text(link is external); Abstract(link is external))

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M. Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2016 Oct 17;2:16189. (Full Text(link is external); Abstract(link is external))

Mejias-Luque, R., J. Zoller, F. Anderl, E. Loew-Gil, M. Vieth, T. Adler, D.B. Engler, S. Urban, J.L. Browning, A. Muller, M. Gerhard, and M. Heikenwalder (2017). Lymphotoxin beta receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner. Gut. 66:1369-1381.(Full Text(link is external); Abstract(link is external))

Wüstner S, Anderl F, Wanisch A, Sachs C. Steiger K, Nerlich A, Vieth M, Mejías-Luque R, Gerhard M. Helicobacter pylori γ-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence Scientific Reports volume 7, Article number: 13636 (2017) (Full Text(link is external); Abstract(link is external))

Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Pantelis Hatzis, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH and Gerhard M. The stem-cell E3 ligase RNF43 displays a novel mode of Wnt inhibition downstream of (mutated) β-catenin, which is disrupted in tumors bearing RNF43 mutations. Science Signaling 2015 Sep 8;8(393):ra90. (Full Text(link is external); Abstract(link is external))

Wüstner S, Mejías-Luque R, Koch M, Rath E, Vieth M, Sieber SA, Haller D, Gerhard M. H. pylori γ-glutamyltranspeptidase impairs T lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression. Cellular microbiology 2015; 17: 51-61. (Full Text(link is external); Abstract(link is external))

Anderl F, Gerhard M. Helicobacter pylori vaccination: Is there a path to protection? World J Gastroenterol. 2014 Sep 14;20(34):11939-11949.(Full Text; Abstract(link is external))

Semper RP, Mejías-Luque R, Groß C, Anderl F, Oertli M, Engler D, Müller A, Vieth M, Busch DH, Prazeres da Costa C, Ruland J, Groß O and Gerhard M. Helicobacter pylori-induced IL-1β secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the Cag Pathogenicity Island. J Immunol., 2014 Oct 1;193(7):3566-76. (Full Text(link is external); Abstract(link is external))(link is external)

Käbisch R, Mejías-Luque R, Gerhard M and Prinz C. Involvement of Toll-like Receptors on Helicobacter pylori-induced immunity. PLos One, 2014 Aug 25;9(8):e104804. (Full Text; Abstract(link is external))

Kalali B, Mejías-Luque R, Javaheri A, Gerhard M. H. pylori virulence factors: influence on immune system and pathology. Mediators Inflamm. 2014;2014:426309. (Full Text; Abstract(link is external))

Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Scheneider RM, Blum H, Wagner E, Jung A, Gerhard M. The stem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells. Carcinogenesis. 2014 Apr;35(4):942-50. (Full Text; Abstract(link is external))

Käbisch R, Mejías-Luque R, Prinz C, Gerhard M. Helicobacter pylori CagA impairs dendritic cell maturation and function through IL-10-mediated activation of STAT3. J Immunol. 2014 Jan 1;192(1):316-23 (Full Text; Abstract(link is external))

Pan KF, Formichella L, Zhang L, Zhang Y, Ma JL, Li ZX, Liu C, Wang YM, Goettner G, Ulm K, Classen M, You WC, Gerhard M. Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a chinese population. Int J Cancer. 2014 May 1;134(9):2118-25. (Full Text; Abstract(link is external))

Khalifeh Gholi M, Kalali B, Formichella L, Göttner G, Shamsipour F, Zarnani AH, Hosseini M, Busch DH, Shirazi MH, Gerhard M. Helicobacter pylori FliD protein is a highly sensitive and specific marker for serologic diagnosis of H. pylori infection. Int J Med Microbiol. 2013 Dec;303(8):618-23. (Full Text(link is external); Abstract(link is external))

Javed S, Mejías-Luque R, Kalali B, Bolz C, Gerhard M. Helicobacter bilis Gamma-Glutamyltranspeptidase Enhances Inflammatory Stress Response via Oxidative Stress in Colon Epithelial Cells. PLoS One. 2013 Aug 23;8(8):e73160. (Full Text; Abstract(link is external))

Formichella L, Romberg L, Bolz C, Vieth M, Geppert M, Göttner G, Nölting C, Walter D, Schepp W, Schneider A, Ulm K, Wolf P, Busch DH, Soutschek E, Gerhard M. A novel immuno-line assay based on recombinant virulence factors enables highly specific and sensitive serological diagnosis of H. pylori infection. Clin Vaccine Immunol. 2013 Nov;20(11):1703-10. (Full Text; Abstract(link is external))

Schmees C, Prinz C, Treptau T, Rad R, Hengst L, Voland P, Bauer S, Brenner L, Schmid RM, Gerhard M. Inhibition of T cell proliferation by Helicobacter pylori γ-glutamyl transpeptidase. Gastroenterology 2007 May;132(5):1820-33. (Full Text(link is external); Abstract(link is external))                                                    

Gerhard M, Schmees C, Voland P,  Endres N, Sander M, Reindl W, Rad R, Oelsner M, Decker T, Mempel M, Hengst L, Prinz C. A secreted low molecular weight protein from Helicobacter pylori induces cell cycle arrest of T-cells. Gastroenterology 2005;128(5):1327-39. (Full Text(link is external); Abstract(link is external))