Postdoc (m/w/d), E13/100 %

We are looking for a scientist (Postdoc, m/w/d) who shares our enthusiasm about human T cell engineering and to work on our new project entitled

"CRISPR-dissection of

human regulatory T cell stability and function”

Our profile

Our team mission is to increase our understanding of human T cell function and stability and the underlying transcriptional networks for future cell therapies against autoimmune diseases and cancer. We developed several CRISPR tools for gene knockouts, gene knockins as well as pooled and arrayed CRISPR screens in primary human T cell subsets (Schumann et al., 2015 PNAS; Hultquist et. al., 2016 Cell Reports; Schumann et al., 2020 Nat Immunol). The focus of the project will be to systematically dissect transcription factor functions in human regulatory T (Treg) cells using state of the art CRISPR screening and cell engineering technologies.

Your profile

  • PhD degree in Immunology, Genetics, Cell Biology, Biology or Biochemistry with outstanding result
  • In-depths experience in immunological techniques and molecular biology
  • Experience in next generation sequencing technologies (such as RNAseq/ATACseq) is beneficial
  • Bioinformatics knowledge (e.g. NGS data analysis with R/python-based tools) is a plus
  • Enthusiasm for basic science and cell engineering
  • Excellent team spirit, presentation, scientific writing and communication skills

Your tasks

  • Analysis of Treg cell stability during inflammation
  • Conducting large scale CRISPR screens in primary human Treg cells
  • Developing functional cell validation assays based on tumor biopsies
  • Conducting scRNA-seq and ATAC-seq analysis of human Treg cells
  • Supervision of (grad) students

We offer

  • Ambitious and innovation-oriented team committed to dissecting, engineering and understanding human T cell functions for future translational approaches
  • Close collaborations with several laboratories at TUM and external partners
  • Well-equipped laboratory in our institute close to Munich city center
  • Full time position as scientist / PostDoc (m/w/d) starting on October 1st 2021 or earlier, currently secured for 36 months (salary according to TV-L)


Are you excited to modulate T cell function? Great! We are looking forward to your email application (CV, letter of motivation and references in one document). TUM seeks to increase the portion of female employees. Qualified females are, therefore, explicitly encouraged to apply. Severely disabled persons with essentially comparable qualifications will be preferentially hired.  

Further questions? We are happy to receive your email or phone call!

Kontakt: Prof. Dr. Kathrin Schumann / +89 41409045/ sends e-mail) /