Busch group, May 2023
The T cell receptor (TCR) serves as the unique fingerprint of a T cell, dictating its target specificity, fate, and functions. T cells employ the TCR to discern between infected or tumor cells and healthy cells. This specific recognition, in turn, triggers effector functions, leading to the elimination of abnormal cells or the support of other immune cells. Our research group is primarily dedicated to unraveling the intricate workings of the TCR, particularly its "avidity" towards its targets, as it fundamentally influences the characteristics of T cells. Concurrently, we aim to apply this knowledge in developing increasingly potent cell therapies using TCR-engineered T cells for combating infectious diseases and cancer.